SevenAge™
NHANES
UK Biobank
Nature · Scientific Reports
The same age can tell two very different health stories.
Chronological age tells you how many birthdays someone has had. Biological age estimates how their body is aging.
Same chronological age, very different trajectories. A biological age assessment helps you:
Preventive care is moving from measuring disease to measuring trajectory.
Patients increasingly arrive with health data, wearable insights and questions about healthy aging.
SevenAge™ helps clinicians anchor that conversation in a validated, clinically meaningful measure — one that reflects the direction a patient's health is heading, not just whether today's values fall in range.
One platform. Three ways to put it to work.
SevenAge™ is designed for use across clinical care, diagnostics and preventive health.
Medical Practices
Offer patients a deeper understanding of their health.
Laboratories
Expand your diagnostic portfolio.
Health Coaches
Turn health coaching into measurable progress.
“SevenAge™ gives me a validated biological age backed by peer-reviewed science, and a report with evidence-based recommendations I can stand behind. Now, aging can be measured, not merely estimated.”
The metric preventive medicine has been missing.
Preventive care has lacked a single number patients understand and clinicians can act on. SevenAge™ gives you both — built from the blood panel your patients already get.
Make health tangible
One number patients understand — turn “your labs look normal” into a plan they actually follow and re-test.
See change earlier
Detect shifts before standard markers flag risk — age acceleration shows up to 5 years before type 2 diabetes or chronic kidney disease.
Track progress over time
Turn follow-ups into measurable progress. Add biological age to routine bloodwork and track change over time.
Seven inputs. Three physiological domains. One biological age.
The model was developed from an initial candidate set of 34 blood biomarkers (see the study). After accounting for biomarker availability and cohort size, highly correlated markers were removed and the remaining biomarkers were iteratively evaluated. The final panel retained the smallest set before predictive performance began to decline: six routine blood biomarkers plus biological sex.
Designed for clinical practice.
SevenAge™ extends those same biomarkers into an integrated biological age assessment designed for longitudinal preventive care.
Routine blood work
Built for routine clinical care
Epigenetic and multi-omic clocks
“SevenAge™ derives a validated measure of biological ageing from a small number of routine biomarkers and, at the cohort level, shows associations with health and chronic disease, in some cases years before diagnosis.”
Fits into the workflow you already run.
SevenAge™ uses HbA1c, HDL, triglycerides, ALT, albumin and creatinine — biomarkers already in your routine panel. No specialised assays. No new laboratory workflow.
Connect once
One-time API or web portal integration.
Continue your normal workflow
Routine blood draw. Results flow through your existing workflow.
Biological age calculated automatically
Report ready in ~15 sec
From result to action
Explain biological age in context.
Identify the biomarker drivers.
Discuss science-based recommendations.
Track change over time.
One-time integration
Uses existing blood tests
Automatic report generation
Longitudinal monitoring
A plan your patients can act on Monday.
Every report combines biological age, the biomarker drivers behind it, and evidence-based insights to facilitate health discussions - all in one report.
A report patients understand and take home.
Patients don't leave with numbers. They leave with a plan.
Peer-reviewed evidence.
SevenAge™ was developed using routine blood biomarkers and published in Scientific Reports (Nature Portfolio, 2025). The model was trained on 59,741 samples and validated in independent cohorts from US NHANES and the UK Biobank, demonstrating generalisability across three continents.
Validated in US NHANES & UK Biobank. Generalisable across three continents.
Each additional year of biological age acceleration was associated with a 3.7% higher hazard of mortality, independent of chronological age, sex and BMI (NHANES validation cohort).
Used across preventive care.
In use today across hospital outpatient clinics, preventive GP practices and executive health programmes.
Make biological age a routine measure in preventive health.
Integrate SevenAge™ under the SevenAge™ brand or as a white-label solution within your existing health offering.
Clinics & hospitals
Add biological age to preventive assessments.
Laboratories & diagnostics
Extend your diagnostic portfolio with biological age.
Corporate & executive health
Make preventive programmes measurable over time.
Everything your team needs to evaluate SevenAge™.
Scientific publication
Peer-reviewed evidence published in Scientific Reports.
Read publication ↗ ProductSample patient report
See exactly what clinicians and patients receive.
Download report ↓ PDFClient brochure
Help clients understand why knowing their biological age matters.
Download brochure ↓What clinicians and institutions ask most.
What makes SevenAge™ a “medical-grade” aging clock?+
Built on 59,741 clinical samples and externally validated in NHANES and the UK Biobank. In healthy individuals, it estimates chronological age to within 4.7 years on average and explains 80% of its variance.
How is SevenAge™ different from other biological age clocks?+
SevenAge™ uses six routine blood biomarkers, making it more accessible and cost-effective than epigenetic or multi-omic clocks while maintaining competitive accuracy among blood-based methods.
Where does the name SevenAge™ come from?+
SevenAge™ uses seven inputs: six routine laboratory biomarkers including creatinine, HbA1c, ALT, albumin, HDL, and triglycerides, plus biological sex. These biomarkers represent three health domains, while biological sex serves as a covariate that calibrates the expected range of each marker. Seven inputs. One biological age.
Why only six markers plus sex — and which ones?+
Creatinine (renal), HbA1c, HDL and triglycerides (cardiometabolic), ALT and albumin (hepatic/inflammation) — three health domains in six markers. Biological sex is not a domain: it enters the model as a covariate, so each value is read against the right reference. The value of a clock lies in which markers it measures, not how many: six well-chosen markers spanning distinct domains capture the meaningful aging signal, matching a far larger panel. Because aging shows up as correlated change across these domains, more markers mostly add redundancy.
What does “predicts disease before diagnosis” actually mean?+
In the UK Biobank, individuals who were later clinically diagnosed with type 2 diabetes or chronic kidney disease already showed significantly elevated biological age acceleration up to five years before diagnosis. This pattern extended across multiple chronic conditions. For diabetes, the association remained even among individuals whose HbA1c was below the diagnostic threshold of 6.5% at the time of sampling. Because SevenAge™ integrates six biomarkers simultaneously, it can capture emerging patterns that may not be apparent from any single marker alone.
Will an infection ruin the result?+
Largely, no. Unlike clocks that rely heavily on more variable inflammatory markers such as CRP, SevenAge™ uses stable clinical chemistry biomarkers. In the UK Biobank, individuals with influenza, pneumonia, or COVID-19 showed minimal median acceleration changes (−0.10 and +0.04 years), while biological age acceleration increased across CRP quintiles. This suggests that chronic inflammatory burden is captured, whereas transient immune activation has limited impact.
How does SevenAge™ connect to our systems?+
Two ways. A clinician enters six blood values plus biological sex into a secure web portal and gets the PDF report back in seconds. To automate, send the same values through our REST API and receive reports programmatically. Values adapt to your units — nothing to install.
Can SevenAge™ be offered under our own brand?+
Yes. For selected institutional partners, SevenAge™ is available as a white-label solution and can be integrated into your existing patient or client experience. Contact us to discuss branding and integration requirements.
Is SevenAge™ a diagnostic test?+
No. SevenAge™ is not intended to be a diagnostic test and is not intended to diagnose, treat, or monitor any disease or medical condition. It estimates biological age from demographic information (i.e. age and biological sex) and six routine serum biomarkers and provides a report for informational and preventive health purposes only. The outputs do not replace clinical judgment or professional medical advice and should not be used as a basis for clinical diagnosis or treatment decisions.
KEYONIQ Technologies — science-driven insights for proactive, personalised health management, from Switzerland.
